Endocrine Abstracts

Introduction: Refractory hypothyroidism is associated with significantly increased morbidity and healthcare costs. During the evaluation of refractory disease, a thyroxine absorption test is frequently performed using different protocols. We assessed the usefulness of the supervised rapid thyroxine absorption test in a low-resource setting and formulated a useful model to determine the expected FT4 rise in hypothyroid patients without known malabsorption.<p class="abstext"...

Differentiated thyroid cancer (DTC) is more frequent in women than in men.The aim of the study was to analyze whether factors connected with the female sex could increase the risk of DTC.Material and methods: Ninety nine patients with a mean age±S.D. of 40.5±5.9 years with DTC and 51 healthy women with a mean age of 36.52±8.3 years were examined. Gynecological and obstetric histories were taken and ser...

Objective: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) in patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) during the 8.5 follow up.Research design and methods: This is an 8-year prospective study in a randomly selected urban population including 2838 subjects aged ≥40 years living in Krakow. Seven hundred and six had IGT (387) or IFG (319) based on WHO criteria and 2...

Background: Type 3 neuroendocrine tumors of the stomach (type 3 NETV) are very rare subtypes of NETV with poor prognosis, not fully understood biology and not well investigated diagnostic and therapeutic procedures. The aim of the study was to analyze tumor biology and the outcome of differentiated treatment in patients with type 3 neuroendocrine tumors of the stomach.Methods: A prospective 10 years follow up of five patients with type 3 NETV treated in ...

Introduction: GLP-1 receptors have been fund on different types of neoplasm’ cells and density of these receptors appears to be more frequent in some of them. GLP-1 receptor scanning offers a new approach for successful localization of small or not detectable by other methods insulinomas and other cancers such as MTC, gastrinoma, pheochromocytoma, gastrinoma, etc.Aim of the study: The aim of study was to present first successful experiences with the...

Congenital hyperinsulinism (CHI) is characterised by unregulated insulin secretion from pancreatic β-cells. The most severe forms are associated with defects in SUR1 and Kir6.2 (encoded by ABCC8 and KCNJ11), which form KATP channels in β-cells. Diazoxide therapy often fails in the treatment of CHI and may be due to reduced cell surface expression of KATP channels. We investigated methods to increase surface expression of KATP<...